top of page


After joining TAMU (2019-)

Publications: List

Qian, L., Ouyang, H., Gordils-Valentin, L., Hong, J., Jayaraman, A.*, Zhu, X.* “Identification of Gut Bacterial Enzymes for Keto-Reductive Metabolism of Xenobiotics” ACS Chem. Biol., 2022, 17(7), 1665–1671.


Ouyang, H., Hong, J., Malroy, J., Zhu, X.* "An E. coli-Based Biosynthetic Platform Expands the Structural Diversity of Natural Benzoxazoles" ACS Synth. Biol., 2021, 10(9), 2151–2158.

Publications: News

Li, J., Barber, C., Herman, N., Cai, W., Zafrir, E., Du, Y., Zhu, X., Skyrud, W., Zhang, W. "Investigation of secondary metabolism in the industrial butanol hyper-producer Clostridium saccharoperbutylacetonicum N1-4." J. Ind. Microbiol. & Biot. 2020, 47, 319–328 

Zhang, B., Rajakovich, L., Cura, D., Blaesi, E., Mitchell, A., Tysoe, C., Zhu, X., Streit, B., Rui, Z., Zhang, W., Boal, A., Krebs, C., Bollinger, J. M. “Substrate-triggered formation of a peroxo-Fe2(III/III) intermediate during fatty acid decarboxylation by UndA” J. Am. Chem. Soc. 2019,141(37), 14510-14514.

Before joining TAMU (2013-2019)

Seidel, J., Miao, P., Porterfield, W., Cai, W., Zhu, X., Kim, S., Hu, F., Bhattarai-Kline, S., Min, W., Zhang, W. “Structure–activity–distribution relationship study of anti-cancer antimycin-type depsipeptides” Chem. Commun. 2019, 55, 9379-9382.

Su, M., Zhu, X., Zhang, W. "Probing the acyl carrier protein-enzyme interactions within terminal alkyne biosynthetic machinery" AIChE J. 2018, 64, 4255-4261. (tribute to founders: Jay Bailey)

Zhu, X., Zhang, W. “Terminal alkyne biosynthesis in marine microbes” Methods Enzymol. 2018, 604, 89-112.

Harris, N. C., Sato, M., Herman, N. A., Twigg, F., Cai, W., Liu, J., Zhu, X., Downey, J., Khalaf, R., Martin, J., Koshino, H., Zhang, W. "Biosynthesis of isonitrile lipopeptides by conserved non-ribosomal peptide synthetase gene clusters in Actinobacteria" Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 7025-7030.

Zhu, X., Shieh, P., Su, M., Bertozzi, C. R., Zhang, W. “A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool.” Chem. Commun. 2016, 52, 11239-11242.

Liu, J., Zhu, X., Kim, S., Zhang, W. "Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities." Nat. Prod. Rep. 2016, 33, 1146-1165.

Rui, Z., Harris, N. C., Zhu, X., Huang, W., Zhang, W. "Discovery of a family of desaturase-like enzymes for 1-alkene biosynthesis." ACS Catal. 2015, 5, 7091-7094.

Liu, J., Zhu, X., Zhang, W. "Identifying the minimal enzymes required for biosynthesis of epoxyketone proteasome inhibitors." ChemBioChem. 2015, 16, 2585-2589.

Zhu, X., Su, M., Manickam, K., Zhang, W. "Bacterial genome mining of enzymatic tools for alkyne biosynthesis." ACS Chem. Biol. 2015, 10, 2785-2793.

Zhu, X., Zhang, W. "Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications." Front. Chem. 2015, 3: 11.

Zhu, X., Liu, J., Zhang, W. “De novo biosynthesis of terminal alkyne-labeled natural products.” Nat. Chem.  Biol. 2015, 11, 115-120. (selected as NCB’s greatest hit) news & views NCB's greatest hits

Liu, J., Zhu, X., Seipke, R. F., Zhang, W. “Biosynthesis of antimycins with a reconstituted 3-formamidosalicylate pharmacophore in Escherichia coli.” ACS Synth. Biol. 2015, 4, 559-565.

Rui, Z., Li, X., Zhu, X., Liu, J., Domigan, B., Barr, I., Cate, J., Zhang, W. “Microbial biosynthesis of medium-chain 1-alkenes by a non-heme iron oxidase.” Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 18237-18242highlight in Angew. Chem.

Sandy, M., Zhu, X., Rui, Z., Zhang, W. “Characterization of AntB, a promiscuous acyltransferase involved in antimycin biosynthesis.” Org. Lett. 2013, 15, 3396-3399.

Publications: List
bottom of page