After joining TAMU (2019-)


Qian, L., Ouyang, H., Gordils-Valentin, L., Hong, J., Jayaraman, A.*, Zhu, X.* “Identification of Gut Bacterial Enzymes for Keto-Reductive Metabolism of Xenobiotics” ACS Chem. Biol., 2022, 17(7), 1665–1671.


Ouyang, H., Hong, J., Malroy, J., Zhu, X.* "An E. coli-Based Biosynthetic Platform Expands the Structural Diversity of Natural Benzoxazoles" ACS Synth. Biol., 2021, 10(9), 2151–2158.


Li, J., Barber, C., Herman, N., Cai, W., Zafrir, E., Du, Y., Zhu, X., Skyrud, W., Zhang, W. "Investigation of secondary metabolism in the industrial butanol hyper-producer Clostridium saccharoperbutylacetonicum N1-4." J. Ind. Microbiol. & Biot. 2020, 47, 319–328 

Zhang, B., Rajakovich, L., Cura, D., Blaesi, E., Mitchell, A., Tysoe, C., Zhu, X., Streit, B., Rui, Z., Zhang, W., Boal, A., Krebs, C., Bollinger, J. M. “Substrate-triggered formation of a peroxo-Fe2(III/III) intermediate during fatty acid decarboxylation by UndA” J. Am. Chem. Soc. 2019,141(37), 14510-14514.

Before joining TAMU (2013-2019)

Seidel, J., Miao, P., Porterfield, W., Cai, W., Zhu, X., Kim, S., Hu, F., Bhattarai-Kline, S., Min, W., Zhang, W. “Structure–activity–distribution relationship study of anti-cancer antimycin-type depsipeptides” Chem. Commun. 2019, 55, 9379-9382.

Su, M., Zhu, X., Zhang, W. "Probing the acyl carrier protein-enzyme interactions within terminal alkyne biosynthetic machinery" AIChE J. 2018, 64, 4255-4261. (tribute to founders: Jay Bailey)

Zhu, X., Zhang, W. “Terminal alkyne biosynthesis in marine microbes” Methods Enzymol. 2018, 604, 89-112.

Harris, N. C., Sato, M., Herman, N. A., Twigg, F., Cai, W., Liu, J., Zhu, X., Downey, J., Khalaf, R., Martin, J., Koshino, H., Zhang, W. "Biosynthesis of isonitrile lipopeptides by conserved non-ribosomal peptide synthetase gene clusters in Actinobacteria" Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 7025-7030.

Zhu, X., Shieh, P., Su, M., Bertozzi, C. R., Zhang, W. “A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool.” Chem. Commun. 2016, 52, 11239-11242.

Liu, J., Zhu, X., Kim, S., Zhang, W. "Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities." Nat. Prod. Rep. 2016, 33, 1146-1165.

Rui, Z., Harris, N. C., Zhu, X., Huang, W., Zhang, W. "Discovery of a family of desaturase-like enzymes for 1-alkene biosynthesis." ACS Catal. 2015, 5, 7091-7094.

Liu, J., Zhu, X., Zhang, W. "Identifying the minimal enzymes required for biosynthesis of epoxyketone proteasome inhibitors." ChemBioChem. 2015, 16, 2585-2589.

Zhu, X., Su, M., Manickam, K., Zhang, W. "Bacterial genome mining of enzymatic tools for alkyne biosynthesis." ACS Chem. Biol. 2015, 10, 2785-2793.

Zhu, X., Zhang, W. "Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications." Front. Chem. 2015, 3: 11.

Zhu, X., Liu, J., Zhang, W. “De novo biosynthesis of terminal alkyne-labeled natural products.” Nat. Chem.  Biol. 2015, 11, 115-120. (selected as NCB’s greatest hit) news & views NCB's greatest hits

Liu, J., Zhu, X., Seipke, R. F., Zhang, W. “Biosynthesis of antimycins with a reconstituted 3-formamidosalicylate pharmacophore in Escherichia coli.” ACS Synth. Biol. 2015, 4, 559-565.

Rui, Z., Li, X., Zhu, X., Liu, J., Domigan, B., Barr, I., Cate, J., Zhang, W. “Microbial biosynthesis of medium-chain 1-alkenes by a non-heme iron oxidase.” Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 18237-18242highlight in Angew. Chem.

Sandy, M., Zhu, X., Rui, Z., Zhang, W. “Characterization of AntB, a promiscuous acyltransferase involved in antimycin biosynthesis.” Org. Lett. 2013, 15, 3396-3399.